Neonatal Abstinence Syndrome: The Use of Clonidine as a Treatment Option

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Neonatal Abstinence Syndrome: The Use of Clonidine as a Treatment Option

product/device. Abstract Infants exposed to opioids in utero and postnatally are at risk for developing withdrawal symptoms upon discontinuation of the drugs. This condition is known as the neonatal abstinence syndrome (NAS). Different medications have been used to ameliorate the symptoms of withdrawal, most commonly opioids. Clonidine has also been evaluated both as an additive and alternative...

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Morphine versus clonidine for neonatal abstinence syndrome.

OBJECTIVE The study goal was to determine whether clonidine treatment of neonatal abstinence syndrome (NAS) would result in a better neurobehavioral performance compared with morphine. METHODS This pilot study prospectively enrolled infants ≥ 35 weeks' gestational age admitted for treatment of NAS. After informed consent was obtained, infants were randomized to receive morphine (0.4 mg/kg per...

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Treatment of neonatal abstinence syndrome.

Neonatal abstinence syndrome (NAS) is suffered by infants withdrawing from substances on which they have become physically dependent after in utero exposure. They may require prolonged treatment and spend weeks or even months in hospital. A wide range of drugs have been used to treat NAS. The efficacy of few, however, have been adequately investigated. Evidence suggests that opioids are the mos...

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Neonatal Abstinence Syndrome: Presentation and Treatment Considerations.

The increase in opioid use among the general population is reflected in pregnant women and neonatal abstinence syndrome (NAS) statistics. This increase has produced an unprecedented focus on NAS from both the political-judicial sphere and the medical community. Under the banner of fetal protection, judges and prosecutors have implemented punitive approaches against women who use prescribed and ...

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Neonatal abstinence syndrome after maternal methadone treatment.

Thirty two infants born to mothers taking methadone and 32 matched controls were studied to determine the incidence, timing, and frequency of persistence of withdrawal signs in infants born to maternal methadone users. Twelve (37%) infants received treatment for symptoms of withdrawal. The median length of time from birth to initiation of treatment was 23 hours (range 15-64 hours), the median l...

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ژورنال

عنوان ژورنال: NeoReviews

سال: 2011

ISSN: 1526-9906,1526-9906

DOI: 10.1542/neo.12-10-e575